When launched in 1957, Lenin was powered by three OK-150 reactors. In its late-1960s configuration, at full capacity the ship used five to six pounds of uranium-235 per 100 days.

In the configuration employed from 1970, two OK-900 reactors provided steam for four steam turbines, that were in turn connected to generators, which powered three sets of electric motors to drive the ship's three propellers.

In February 1965, there was a loss-of-coolant accident. After being shut down for refueling, the coolant was removed from the number two reactor before the spent fuel had been removed. As a result, some of the fuel elements melted and deformed inside the reactor. This was discovered when the spent elements were being unloaded for storage and disposal. 124 fuel assemblies (about 60% of the total) were stuck in the reactor core. It was decided to remove the fuel, control grid, and control rods as a unit for disposal; they were placed in a special cask, solidified, stored for two years, and dumped in Tsivolki Bay (near the Novaya Zemlya archipelago) in 1967.

The second accident was a cooling system leak which occurred in 1967, shortly after refueling. Finding the leak required breaking through the concrete and metal biological shield with sledgehammers. Once the leak was found, it became apparent that the sledgehammer damage could not be repaired; subsequently, all three reactors were removed by blowing them off the ship with shaped charges above a burial site off Novaya Zemlya, and replaced by two OK-900 reactors. This was completed in early 1970.

Lenin was decommissioned in 1989, because its hull had worn thin from ice friction. She was laid up at Atomflot, a base for nuclear icebreakers in Murmansk, and according to Pravda.ru, repair and conversion into a museum ship was completed in 2005.